Chronic neurodegenerative diseases are a group of devastating neurological disorders that result in significant morbidity and\nmortality in the elderly population worldwide. Recent researches have shown some interesting associations of the classical\nantiobesity hormone leptin with two most important neurodegenerative diseasesââ?¬â?Alzheimerââ?¬â?¢s disease (AD) and Parkinsonââ?¬â?¢s\ndisease (PD). Although several clinical studies have found the procognitive and memory-enhancing role of this peptide hormone\nin leptin-deficient patients, surprisingly it has not been used in any clinical trials involving patients with developing or fullblown\nneurodegenerative conditions. This review article is an attempt to bring together the existing information about the clinical\nassociations of leptin with AD and PD. It starts with the basic understanding of leptin action in the brain and its derangements in\nthese diseases and eventually discusses the potential of this hormone as a neuroprotective agent in clinical scenario.
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